Typical usage: :Disorders of calcium balance, Edema, Heart failure, Hypertension, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetes insipidus.
Probable Side Effects: :Dizziness, Thirst, Headache, Nausea, Gout, Impotence, Polyuria, Night cramps.
Drug Interaction: None mentioned.
Mechanism of Action: Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: :It is used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure
Probable Side Effects: :Dizziness, back pain, sinusitis, pharyngitis and diarrhoea.
Drug Interaction: Telmisartan is known to interact with other drugs like acetylsalicylic acid, amifostine, amiloride, diclofenac, digoxin, fenoprofen, flurbiprofen, ketoprofen, ketorolac, lumiracoxib, meloxicam, nabumetone, spironolactone, tiaprofenic acid, tolmetin, trandolapril. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone and improve carbohydrate and lipid metabolism.
Pregnancy Impact: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Price of Arbitel H 40/12.5Mg 10 Tablet : Rs.100.00
Hydrochlorothiazide 12.5 mg, Telmisartan 40 mg
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