Bosentas 62.5mg 10Tablet contains following Salts:-
Bosentan - Drug Information
Indications Bosentan is primarily indicated in conditions like Nausea and vomiting (palliative care).
Dosage Adult: PO Pulmonary HTN >12 yr <40 kg: Initial and maintenance: 62.5 mg bid; ?40 kg: Initial: 62.5 mg bid for 4 wk. Maintenance: 125 mg bid. Systemic sclerosis w/ ongoing digital ulcer ?18 yr <40 kg: Initial and maintenance: 62.5 mg bid; ?40 kg: Initial: 62.5 mg bid for 4 wk. Maintenance: 125 mg bid.
Contra-Indications Acute porphyria; moderate and severe hepatic impairment. Coadministration w/ ciclosporin or glibenclamide. Pregnancy (use 2 forms of contraception during treatment and 1 mth after stopping).
Side Effects Headache, nasopharyngitis, flushing, fluid retention (e.g. peripheral oedema), hypotension, palpitations, dyspepsia, fatigue, pruritus, rash, anaemia (dose-related), reduced sperm count (reversible).
Special Precautions Consider discontinuation of therapy if pulmonary oedema occurs. Avoid abrupt withdrawal and consider dose reduction (e.g. half the dose for 3-7 days) to minimise risk of clinical deterioration. Lactation. Monitoring Parameters Monitor hepatic function before initiating therapy and mthly thereafter, and 2 wk after any dose increment. Monitor haemoglobin levels before initiating therapy, mthly during the 1st 4 mth, then quarterly thereafter
Drug-Interaction Increased bosentan levels w/ CYP3A4 inhibitors (e.g. ketoconazole, ritonavir, diltiazem), CYP2C9 inhibitors (e.g. amiodarone, fluconazole), tacrolimus. Rifampicin initially increases but subsequently decreases bosentan concentration. May decrease plasma levels of warfarin, statins (e.g. simvastatin, lovastatin), hormonal contraceptives, sildenafil, tadalafil. Potentially Fatal: Increased risk of hepatotoxicity may occur w/ glibenclamide. Ciclosporin markedly increases bosentan concentration.
Price of Bosentas 62.5mg 10Tablet : Rs.690.00
|Dispatches by||Next Day|
|Composition||Bosentan 65 mg|
|Pack Size||10 Tablet|
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Substitutes of Bosentas 62.5mg 10Tablet
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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