Indications Treatment Of Coronary Artery Disease, Treatment Of Chronic Heart Failure.
Dosage Adult: PO Chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm who are unable to tolerate or has a contraindication to beta-blockers; or used with beta-blockers in patients inadequately controlled with an optimal dose of beta-blockers and whose heart rate is >60 beats/min Initial: 5 mg twice daily. Increase if necessary to 7.5 mg twice daily after 3-4 weeks. Titrate downward to 2.5-5 mg twice daily if develop bradycardia (resting heart rate < 50 beats/min) or experience symptoms of bradycardia (dizziness, fatigue, hypotension).
Contra-Indications Pregnancy, lactation, resting heart rate <60 beats/min prior to treatment, cardiogenic shock, acute myocardial infarction, severe hypotension (<90/50 mmHg), severe hepatic insufficiency, sick sinus syndrome, sino-atrial block, heart failure patients with NYHA class III-IV, pacemaker dependent, unstable angina, 3rd degree AV-block, concurrent use with potent CYP3A4 inhibitors.
Special Precautions Reduce dose if resting heart rate is persistently <50 beats/min or patient develops bradycardia symptoms during treatment; discontinue if heart rate <50 beats/min and symptoms persist. Not recommended in patient with AF or other cardiac arrhythmias that interfere with sinus node rhythm; monitor regularly for AF occurrence. Not recommended for concomitant use with heart rate reducing calcium channel blockers (e.g. diltiazem or verapamil), immediate use after a stroke or in patients with 2nd degree AV-block. Moderate hepatic insufficiency. Stop treatment if visual field deteriorates unexpectedly. Patients with retinitis pigmentosa.
Drug-Interaction Ivabradine Is Known To Interact With Other Drugs Like Ketoconazole, Macrolide Antibiotics, Cyclosporin, Gestodene, Anti-retroviral Drugs, Verapamil. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Price of Coralan 5Mg 14Tablet : Rs.275.00
Ivabradine 5 mg
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