Crophen 10Mg contains following Salts:-
Paracetamol - Drug Information
Typical usage: :Ear pain, fever, headache, malaise, migraine, mild to moderate pain, pain, post-vaccine reaction, short-bowel syndrome.
Probable Side Effects: :Bronchospasm, blood dyscrasias, centribular necrosis, liver damage, hypoglycemic coma, hepatic necrosis, liver failure, skin rashes, GI adverse effects.
Drug Interaction: Paracetamol is known to interact with other drugs like alcohol, ascorbic acid, azilisartan medoxomil, busulphan, carbamazepine, chloramphenicol, cimetidine (HCl), diflunisal, interferon alpha, isoniazid, itopride (HCl), metoclopramide (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Paracetamol is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Paracetamol indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. paracetamol is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. The antipyretic properties of paracetamol are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Promethazine - Drug Information
Typical usage: :Acceleration of myeloid recovery following bone marrow transplantation, Adjunct in ganciclovir treatment, Advanced ovarian cancer, All forms of epilepsy, Allergy, Anaphylactic reactions, Dermatologicals, Haemolytic disease of newborn, Insect bites, Insomnia, Metastatic germ cell cancers (seminoma and teratoma), Motion sickness, Myoclonus, Nausea.
Probable Side Effects: :Seizures, Blurred vision, Respiratory depression, Hallucinations, Delirium, Ataxia, CNS stimulation, Anxiety, Deep sleep, Akathisia, Hyperexcitability.
Drug Interaction: Masks ototoxicity of aminoglycoside antibiotics.
Mechanism of Action: Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong ?-adrenergic blocking effect. It competitively binds to H1-receptors.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Price of Crophen 10Mg : Rs.8.00
|Dispatches by||Next Day|
|Composition||Paracetamol 500 mg, Promethazine 10 mg|
|Salt Information||Paracetamol, Promethazine|
|Brand Name||Shalaks Pharmaceticals Pvt Lt|
|Pack Size||10 Tablet|
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Substitutes of Crophen 10Mg
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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