Daivobet Ointment 15Gm contains following Salts:-
Betamethasone - Drug Information
Typical usage: :Replacement therapy: Adrenal insufficiency. Adrenogenital syndrome. Nonendocrine diseases: Rheumatoid arthirits. Osteoarthritis, Acute gouty arthirits. Collagen diseases e.g. systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, nephritic syndrome, glomerulonephritis and related diseases. Severe allergic reactions e.g. anaphylaxis, angioneurotic edema, urticaria and serum sickness and related diseases. Autoimmune diseases e.g. haemolytic anaemia, idiopathic thrombocytopenic purpura, active chronic hepatitis and related diseases. Other lung diseases e.g. pulmonary edema, accelerate lung maturation and surfactant production in the foetus and prevent respiratory distress syndrome at birth. Infective diseases e.g. severe forms of tuberculosis, severe lepra reaction, certain forms of bacterial meningitis and Pneumocystis carinii pneumonia with hypoxia in AIDS patients along with proper antibiotic cover. Eye diseases e.g. inflammatory ocular diseases, allergic conjunctivitis, iritis, iridocyclitis, keratitis, retinitis, optic neuritis, uveitis. Skin diseases e.g. eczematous skin diseases. Pemphigus vulgaris, exfoliative dermatitis, Stevens Johnson syndrome. Intestinal diseases e.g. ulcerative colitis, Crohns disease, coeliac disease are chronic inflammatory intestinal diseases. Cerebral edema. Malignancies e.g. Acute lymphatic leukaemia, Hodgkins and other lymphomas. Hormone responsive breast carcinoma. Organ transplantation and skin allograft. Septic shock. Thyroid storm.
Probable Side Effects: :Atrophy, steroid purpura, steroid purpura, skin fragility, angioedema, perioral dermatitis, vertigo, headache, diarrhea, fever, anxiety, constipation, abdominal pain, sweating, erythema, hypotension, arthralgia, acne, hypersensitivity reactions, menstrual irregularity, cataract, hypertrichosis, pigmentation, superficial blood vessels dilatation, local hypopigmentation.
Drug Interaction: Betamethasone is known to interact with other drugs like amphotericin B, carbamazepine, lofexidine, metyrosine, oxandrolone, perindopril, phenytoin (Na), rifampicin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibits arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.
Pregnancy Impact: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Calcipotriol - Drug Information
Typical usage: :Topical treatment of psoriasis.
Probable Side Effects: :Weakness, headache, fatigue, anorexia, abdominal pain, erythema, weight Loss, contact dermatitis, hot flushes, local irritation, facial dermatitis, xerosis.
Drug Interaction: No data regarding the interactions of calcipotriol was found.
Mechanism of Action: The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it has been shown to have comparable affinity with calcitriol for the Vitamin D receptor, while being less than 1% as active as the calcitriol in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Price of Daivobet Ointment 15Gm : Rs.774.00
|Dispatches by||Next Day|
|Composition||Betamethasone 0.5 mg, Calcipotriol 50 mcg|
|Salt Information||Betamethasone, Calcipotriol|
|Brand Name||Win Medicare|
|Pack Size||15 gm|
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Substitutes of Daivobet Ointment 15Gm
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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