Drug Interaction: Furazolidone is known to interact with other drugs like adrenaline, albuterol, alcohol, amitriptyline (HCl), carbamazepine, dopamine (HCl), doxapram, ephedrine, levodopa, maprotiline (HCl), metaraminol, methylamphetamine, methyldopa.
Mechanism of Action: Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Typical usage: :Amoebiasis, giardiasis, trichomonas vaginitis, anaerobic infections, ulcerative gingivitis. Eradication of H.pylori associated with peptic ulcer disease. Antibiotic-associated coulitis. Trichomoniasis, Balantidiasis, Blastocyatis hominis infection. Adjunct to treatment of chronic periodontal infections. Rosacea.
Probable Side Effects: :GI disturbances e.g. nausea, unpleasant metallic taste, vomiting, diarrhoea or constipation. Furred tongue, glossitis, and stomatitis due to overgrowth of Candida. Rarely, antibiotic-associated colitis. Weakness, dizziness, ataxia, headache, drowsiness, insomnia, changes in mood or mental state. Numbness or tingling in the extremities, epileptiform seizures (high doses or prolonged treatment). Transient leucopenia and thrombocytopenia. Hypersensitivity reactions. Anaphylaxis.
Drug Interaction: Acute psychoses or confusion with disulfiram. It has synergistic effect with other antimicrobials. Effects reduced with phenobarbital or phenytoin. Disulfiram-like reaction with alcohol. Increased risk of adverse effects of coumarin anticoagulants, phenytoin, lithium, ciclosporin, fluorouracil. Increased risk of neurological effects with cimetidine.
Mechanism of Action: Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is effective against a wide range of organisms including E. histolytica, T. vaginalis, Giardia, anaerobes e.g. Bacterioides sp, Fusobacterium sp, Clostridium sp.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.
Price of Dependal M 10Tablet : Rs.5.13
Furazolidone 100 mg, Metronidazole 300 mg
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