Probable Side Effects: :Proximal myopathy, encephalopathy, dementia, diarrhea, constipation.
Drug Interaction: Aluminium Hydroxide and Oxide is known to interact with other drugs like alfacalcidol, azithromycin, calcitriol, carbenoxolone (Na), cefpodoxime, chlordiazepoxide (HCl), chloroquine, cimetidine (HCl), citric acid, clopidogrel, diacerein, diflunisal, digoxin, ethambutol (HCl), etidronate (Disodium), fluoride, hydroxychloroquine (Sulphate), indomethacin, iron salts, isoniazid, ketoconazole. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Drug Interaction: Magnesium hydroxide is known to interact with other drugs like calcium gluconate, chlorpropamide, ciprofloxacin, diflunisal, digoxin, doxycycline, fluoride, iron salts, isoniazid, meclofenamate, moxifloxacin, mycophenolate, naproxen, nitrofurantoin, phenoxymethylpenicillin (K), phenylbutazone, prednisolone and prednisone, propranolol (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium supplements have also been shown to reduce platelet aggregation by inhibiting in the influx of calcium, a crucial component of platelet aggregation.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.
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