Dukinase 0.1 Million Iu contains following Salts:-
Urokinase - Drug Information
Indications Urokinase is primarily indicated in conditions like Arterial thrombosis, Hyphaema, Myocardial infarction, Pulmonary embolism, Thrombosis.
Dosage Adult: IV Deep vein thrombosis; Pulmonary embolism Initial: 4,400 u/kg over 10 mins, then 4,400 u/kg/hr for 12-24 hr (deep vein thrombosis) or 12 hr (pulmonary embolism). Acute MI 2-3 million u as infusion. Peripheral arterial thromboembolism As 2,000 u/ml soln: Infuse into a clot via a catheter at a rate of 4,000 u/min for 2 hr. Monitor response using angiography. If clot is not removed, the catheter is advanced into the occluded vessel and continue infusion for another 2 hr. May repeat procedure up to 4 times if needed. If blood flow is re-established, partially remove cathether and infuse at 1,000 u/min till remaining clot has lysed. Inj Clearance of occluded catheters and shunts Instill 5,000 - 25,000 u into affected IV catheter or shunt and clamped for up to 4 hr. Aspirate the lysate and repeat the procedure if needed. Irrigation Break down of clots in hyphaema Dissolve 5,000 u in 2 mL of sterile distilled water. Irrigate the anterior chamber with 0.3 mL of the prepared soln and leave it in situ for 3 mins before washing out w/ saline. Repeat 5 times. May leave 0.3 mL in the anterior chamber for 24-48 hr if residual clot is still present at the end
Contra-Indications Active internal bleeding; history of cerebrovascular accident; recent (within 2 mth) trauma of any kind including surgery; aneurysm; known bleeding diathesis; severe uncontrolled hypertension. Recent history of peptic ulcer disease, oesophageal varices, ulcerative colitis or other bleeding GI lesions; pancreatitis; subacute bacterial endocarditis; coagulation defects including those due to liver or kidney disease, or after recent surgery, childbirth or trauma. Increased risk of cerebral bleeding e.g. recent stroke or cerebral neoplasm. Pregnancy.
Side Effects Bleeding, pyrexia, haematuria, thromboembolic episodes, hypersensitivity reactions.
Special Precautions Any vascular punctures or invasive procedures should be avoided as far as possible during, and immediately before and after urokinase therapy and if unavoidable done with great care. External chest compression. Caution in conditions eg, possibility of left heart thrombus, subacute bacterial endocarditis, coagulation defects, cerebrovascular disease, diabetic retinopathy and any conditions in which bleeding could be dangerous. Monitor for reperfusion arrhythmias when used in MI.
Drug-Interaction Reduced thrombolytic effect when given again some time later due to development of high levels of antibodies.Potentially Fatal: Platelet inhibitors eg, aspirin and indometacin can potentiate the action of urokinase and cause haemorrhage. Heparin and oral anticoagulants may increase risk of bleeding
Price of Dukinase 0.1 Million Iu : Rs.109.50
|Dispatches by||Next Day|
|Composition||Urokinase 0.1 Million iu|
|Brand Name||Taj Pharma|
|Pack Size||1 Unit in Vial|
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Substitutes of Dukinase 0.1 Million Iu
Rs.1.00Cyper Drugs & Pharma
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Rs.1.00Low Cost Standard Therapeutics (Locost)
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