Efcorlin Nasal (10Ml) contains following Salts:-
Hydrocortisone - Drug Information
Typical usage: :Replacement therapy: Adrenal insufficiency. Adrenogenital syndrome. Nonendocrine diseases: Rheumatoid arthirits. Osteoarthritis, Acute gouty arthirits. Collagen diseases e.g. systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, nephritic syndrome, glomerulonephritis and related diseases. Severe allergic reactions e.g. anaphylaxis, angioneurotic edema, urticaria and serum sickness and related diseases. Autoimmune diseases e.g. haemolytic anaemia, idiopathic thrombocytopenic purpura, active chronic hepatitis and related diseases. Other lung diseases e.g. pulmonary edema, accelerate lung maturation and surfactant production in the foetus and prevent respiratory distress syndrome at birth. Infective diseases e.g. severe forms of tuberculosis, severe lepra reaction, certain forms of bacterial meningitis and Pneumocystis carinii pneumonia with hypoxia in AIDS patients along with proper antibiotic cover. Eye diseases e.g. inflammatory ocular diseases, allergic conjunctivitis, iritis, iridocyclitis, keratitis, retinitis, optic neuritis, uveitis. Skin diseases e.g. eczematous skin diseases. Pemphigus vulgaris, exfoliative dermatitis, Stevens Johnson syndrome. Intestinal diseases e.g. ulcerative colitis, Crohns disease, coeliac disease are chronic inflammatory intestinal diseases. Cerebral edema. Malignancies e.g. Acute lymphatic leukaemia, Hodgkins and other lymphomas. Hormone responsive breast carcinoma. Organ transplantation and skin allograft. Septic shock. Thyroid storm.
Probable Side Effects: :Convulsions, GI bleeding, telangiectasia, striae, glaucoma, cataract, pancreatitis, hypersensitivity reactions, osteoporosis, psychosis, increased intracranial pressure, growth retardation, glucose intolerance, epidermal thinning, vertebral fractures, avascular necrosis, papilloedema, opthalmic fungal or viral disease, dendritic corneal ulcers, thromboembolic disorder, long bone fractures, hypokalemic alkalosis, anaphylactoid reactions, addisonian crises, CHF, opportunistic infections, acute pancreatitis, insomnia, irritation, allergic reactions, itching, burning, depression, weight gain, acne, euphoria, menstrual irregularity, perioral dermatitis.
Drug Interaction: Hydrocortisone is known to interact with other drugs like aminoglutethimide, amobarbital, amphotericin B, ascorbic acid, aspirin, carbamazepine, frusemide or furosemide, gentamicin, ipilimumab, lofexidine, metyrosine, natamycin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production.
Pregnancy Impact: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Naphazoline Nitrate - Drug Information
Typical usage: :Nasal congestion.
Probable Side Effects: :Dizziness, Headache, Nausea, Nervousness, Dry mouth, Irritation, Sneezing, Blurring of vision, Mydriasis, Stinging on application.
Drug Interaction: Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval.
Mechanism of Action: Naphazoline, an imidazoline derivative sympathomimetic amine, produces vasoconstriction by stimulating the ?-adrenergic receptors in the arterioles of the conjunctiva and the nasal mucosa.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Price of Efcorlin Nasal (10Ml) : Rs.24.00
|Dispatches by||Next Day|
|Composition||Hydrocortisone 0.02%, Naphazoline Nitrate 0.025%|
|Salt Information||Hydrocortisone, Naphazoline Nitrate|
|Pack Size||1 Unit|
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Efcorlin Nasal (10Ml) Reviews
Perfect Nasal Drop Review by Dinesh
Price Value Quality
This is the perfect nasal drop, opens the blocked nose in few seconds. (Posted on 9/9/2015)
FAQ on Efcorlin Nasal (10Ml)
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Substitutes of Efcorlin Nasal (10Ml)
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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