Typical usage: :Duodenal ulceration, for prophylaxis in pregnancy, prohylaxis of acid aspiration in obstetric patients.
Probable Side Effects: :Headache, palpitation, tachycardia, insomnia, tremor, peripheral dilatation.
Drug Interaction: Formoterol is known to interact withother drugs like quinidine, disopyramide, procainamide, phenothiazines, antihistamines, MAOI or TCAs, L-dopa, L-thyroxine, oxytocin, alcohol. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Formoterol stimulates the intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibits the release of pro-inflammatory mast-cell mediators such as histamine and leukotrienes.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Foracort 200Mcg Rotacaps 30Capsule : Rs.175.00
Budesonide 200 mcg, Formoterol 6 mcg
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