Geolone Cream 20Gm contains following Salts:-
Fluocinolone - Drug Information
Typical usage: :asthma attacks
Probable Side Effects: :Telangiectasia, striae, glaucoma, cataract, growth retardation, adrenal suppression, epidermal thinning, raised intracranial pressure, allergic reactions, perioral dermatitis, rebound pustulation.
Drug Interaction: Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of oral corticosteroids (e.g., prednisone), drugs that suppress the immune system (e.g., cyclosporine).
Mechanism of Action: Fluocinonide binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Geolone Cream 20Gm : Rs.20.00
|Dispatches by||Next Day|
|Composition||Fluocinolone 0.025% w/w|
|Brand Name||Geolife Sciences|
|Pack Size||20 gm|
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Substitutes of Geolone Cream 20Gm
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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