Indications Naproxen is primarily indicated in conditions like Acute gout, Acute spasm and spasm in diagnostic procedures, Differential diagnosis of acth-dependent cushing`s syndrome, Dysmenorrhoea, Fever, fever, Glaucoma, Headache, Migraine, Musculoskeletal disorders, Ocular hypertension, Pain, Rheumatoid arthritis, Surgical infections, Trauma
Dosage Adult: PO Rheumatic disorders 0.5-1 g/day in 1-2 divided doses. Acute musculoskeletal disorders; Dysmenorrhoea Initial: 500 mg, then 250 mg 6-8 hrly. Max: 1,250 mg on the 1st day and 1,000 mg thereafter. Acute gout Initial: 750 mg, then 250 mg 8 hrly.
Contra-Indications Hypersensitivity to naproxen, aspirin or other NSAIDs. Treatment of perioperative pain in the setting of CABG surgery. Active or history of peptic ulceration or active GI bleeding. History of asthma, urticaria, allergic-type reactions. Severe renal impairment.
Special Precautions Patient w/ known CV disease or risk factors for CV disease, history of GI bleeding or peptic ulceration, fluid retention or heart failure. Hepatic and renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive and operate machinery. Monitoring Parameters BP should be monitored closely during initiation and throughout therapy. Perform periodically renal function, CBC and chemistry profile in patients receiving long-term therapy
Drug-Interaction May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events (e.g. ulcer) w/ aspirin. Increased risk of GI bleeding w/ warfarin. May reduce the natriuretic effects of furosemide or thiazide diuretics. May increase serum lithium concentrations and reduce renal lithium clearance. Delayed absorption w/ antacids, colestyramine or sucralfate. May interfere w/ the antihypertensive effects of ?-blockers (e.g. propranolol). May increase serum levels w/ probenecid.
Drug Interaction: Sumatriptan is known to interact with other drugs like alcohol, citalopram (HBr), dihydroergotamine (Mesylate), ergotamine (Tartrate), fluvoxamine (Maleate), furazolidone, isocarboxazid, naratriptan, nitroglycerin, paroxetine, sertraline (HCl), sibutramine, tranylcypromine (Sulphate). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the CNS. A small but significant delay in gastric emptying also occurs.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Headset 35mg 2Tablet : Rs.72.00
Naproxen 500 mg, Sumatriptan 35 mg
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