Drug Interaction: Medicines that can increase blood sugar can reverse the action of glimepiride. These drugs include diuretics, for example, hydrochlorothiazide (Hydrodiuril, Ezide, Hydro-Par, Microzide, and many combinations with other drugs), furosemide (Lasix), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin),niacin, and sympathomimetics such as pseudoephedrine (Sudafed). Beta blockers such as propranolol (Inderal) and atenolol (Tenormin) can cause low or high blood sugar.
Mechanism of Action: This medication is an oral hypoglycemic (anti-diabetic drug), prescribed for type 2 diabetes.
Pregnancy Impact: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Drug Interaction: Potassium citrate is known to interact with other drugs like amiloride (HCl), spironolactone, triamterene. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: The metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. The changes induced by potassium citrate tablets produce a urine that is less conducive to the crystallization of stone-forming salts (calcium oxalate, calcium phosphate and uric acid). Increased citrate in the urine, by complexing with calcium, decreases calcium ion activity and thus the saturation of calcium oxalate. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate (brushite).
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of K Glim M 2Mg 10Tablet : Rs.31.00
Glimepiride 2 mg, Potassium Citrate 500 mg
Glimepiride, Potassium Citrate
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