Drug Interaction: Ketoconazole is known to interact with other drugs like abiraterone acetate, alcohol, alfentanil (HCl), aliskiren, alprazolam, aluminium hydroxide and oxide, amphotericin B, aprepitant, artesunate, astemizole, beclomethasone (Dipropionate), bosentan, carbamazepine, cimetidine (HCl), cisapride, corticotropin, cyclosporin A, dabigatran, desonide, didanosine, docetaxel, eplerenone, erlotinib, famotidine, fexofenadine, flunisolide, indinavir (Sulphate). Always consult your physician for the change of dose regimen or an alternative drug choice that may strictly be required.
Mechanism of Action: Ketoconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol causes inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.
Price of Ketovate Skin Cream 15 Gm : Rs.110.00
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