Lobate Gn Cream 15Gm contains following Salts:-
Clobetasol Propionate - Drug Information
Neomycin Sulphate - Drug Information
Typical usage: :Decontamination of digestive tract, hepatic coma, hepatic encephalopathy, pre-operative bowel sterilization, sepsis, skin infections
Probable Side Effects: :Urticaria, angioneurotic edema, ototoxicity, blood dyscrasias, anaphylactic shock, renal failure, vertigo, headache, diarrhea, tinnitus, pruritus, lethargy, skin rash, contact dermatitis.
Drug Interaction: Neomycin is known to interact with other drugs like acarbose, atracurium (Besylate), cyanocobalamin, digoxin, doxacurium, fluorouracil, gentamicin, gestodene, hydroxocobalamin, mecobalamin, methotrexate, pancuronium (Br). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Neomycin irreversibly bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Lobate Gn Cream 15Gm : Rs.39.50
|Dispatches by||Same Day|
|Composition||Clobetasol Propionate 0.05%, Neomycin Sulfate 0.5%|
|Salt Information||Clobetasol Propionate, Neomycin Sulphate|
|Pack Size||15 gm|
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Substitutes of Lobate Gn Cream 15Gm
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