Meridol contains following Salts:-
Paracetamol - Drug Information
Typical usage: :Ear pain, fever, headache, malaise, migraine, mild to moderate pain, pain, post-vaccine reaction, short-bowel syndrome.
Probable Side Effects: :Bronchospasm, blood dyscrasias, centribular necrosis, liver damage, hypoglycemic coma, hepatic necrosis, liver failure, skin rashes, GI adverse effects.
Drug Interaction: Paracetamol is known to interact with other drugs like alcohol, ascorbic acid, azilisartan medoxomil, busulphan, carbamazepine, chloramphenicol, cimetidine (HCl), diflunisal, interferon alpha, isoniazid, itopride (HCl), metoclopramide (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Paracetamol is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Paracetamol indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. paracetamol is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. The antipyretic properties of paracetamol are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Tramadol - Drug Information
Typical usage: :Moderate to severe pain, pain, parkinson's disease, drug-induced extrapyramidal symptoms.
Probable Side Effects: :Seizures, physical dependence, coma, respiratory depression, shock, dizziness, headache, nausea, vomiting, diarrhea, restlessness, constipation, dry mouth, pruritus, somnolence, bronchospasm, angioedema.
Drug Interaction: Tramadol is known to interact with other drugs like carbamazepine, cyclobenzaprine hydrochloride, lithium, noradrenaline (Acid Tartrate), ondansetron (HCl), opium, oxymorphone, paregoric, phenelzine, quinidine, warfarin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Price of Meridol : Rs.45.00
|Dispatches by||Next Day|
|Composition||Paracetamol 500 mg, Tramadol 50 mg|
|Salt Information||Paracetamol, Tramadol|
|Pack Size||10 Tablet|
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Substitutes of Meridol
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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