Nitrofix As contains following Salts:-
Aspirin - Drug Information
Indications Aspirin is primarily indicated in conditions like Fever, Following coronary bypass surgery, Headache, Inflammation, Ischaemic event (unstable angina, myocardial infarction), Mild to moderate pain, Myocardial infarction, Myocardial infarction prophylaxis, Pain and inflammation (in rheumatic disease, in other musculoskeletal disorders), Prophylaxis of cerebrovascular disease, Pyrexia, Stable angina, Stable angina pectoris, Stroke prophylaxis, and can also be given in adjunctive therapy as an alternative drug of choice in Arterial thromboembolism prophylaxis, Colorectal carcinoma prophylaxis, Juvenile rheumatoid arthritis, Neurogenic bladder, Osteoarthritis.
Dosage Adult: PO Prophylaxis of MI 75-325 mg/day. Stent implantation 325 mg 2 hr pre-op, then 160-325 mg/day. Pain and fever 325-650 mg 4-6 hrly. Max: 4 g/day. Pain and inflammation associated w/ musculoskeletal and joint disorders Initial: 2.4-3.6 g/day. Maintenance: 3.6-5.4 g/day.
Contra-Indications Aspirin is contraindicated in conditions like GI ulceration,Hypoprothrombinemia,Hypersensitivity.
Side Effects The signs and symptoms that are produced after the acute overdosage of Aspirin include Coma, Acidosis, Hyperthermia, Volume depletion, Hyperglycemia, Renal failure, Hyperventilation, Cardiovascular collapse, Vertigo, Tinnitus, Hyperkalemia. The symptomatic adverse reactions produced by Aspirin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Nausea, Vomiting, Tinnitus, Epigastric discomfort, Dyspepsia, Asthma, Respiratory alkalosis, Bleeding.Aspirin produces potentially life-threatening effects which include Cerebral hemorrhage, Airway obstruction, Gastric ulceration, Gastric erosion. which are responsible for the discontinuation of Aspirin therapy.The severe or irreversible adverse effects of Aspirin, which give rise to further complications include Urticaria, Gi bleeding, Rhinitis, Angioneurotic edema, Hepatitis, Hepatomegaly.
Special Precautions History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion, asthma or allergic disorders, dehydrated patients, uncontrolled hypertension, impaired renal or hepatic function, elderly.
Drug-Interaction Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone.May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.
Isosorbide Mononitrate - Drug Information
Typical usage: :For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Probable Side Effects: :Tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion, nausea, vomiting, abdominal pain, restlessness, weakness and vertigo, dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea.
Drug Interaction: Isosorbide mononitrate is known to interact with other drugs like avanafil, dihydroergotamine, dihydroergotoxine, ergonovine, methylergonovine, sildenafil, telithromycin, udenafil, voriconazole. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Isosorbide mononitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Nitrofix As : Rs.25.00
|Dispatches by||Next Day|
|Composition||Aspirin 150 mg, Isosorbide Mononitrate 30 mg|
|Salt Information||Aspirin, Isosorbide Mononitrate|
|Brand Name||Micro Labs|
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Substitutes of Nitrofix As
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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