Drug Interaction: Clindamycin is known to interact with other drugs like bamifylline, calcium gluconate, distigmine (Br), gentamicin, lincomycin (HCl), pancuronium (Br), physostigmine, rivastigmine, rocuronium (Br), sodium thiosulphate.
Mechanism of Action: Systemic/vaginal clindamycin inhibits protein synthesis of bacteria by binding to the 50S ribosomal subunits of the bacteria. Specifically, it binds primarily to the 23s RNA subunit. Topical clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Peroclin 2.5% Gel : Rs.269.00
Benzoyl Peroxide 1, Clindamycin
Benzoyl Peroxide, Clindamycin
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