Polybion Caps 15S contains following Salts:-
Cyanocobalamin - Drug Information
Typical usage: :Addisonian pernicious anaemia, Congenital cobalamine malabsorption, Congenital intrinsic factor deficiency, Homocystenemia, Ileal resection, Methylmalonylacidurias, Nutrition deficiency, Post gastrectomy vit B-12 deficiency, Transcobalamin II deficiency, and can also be given in adjunctive therapy as an alternative drug of choice in Vitamin-B12 defeciency of dietary origin.
Probable Side Effects: :Hypersensitivity reactions, Shivering, Dyspnea, Persistant urticaria, Bronchospasm.
Drug Interaction: Cyanocobalamin is known to interact with other drugs like Alcohol, Chloramphenicol, Cholestyramine, Colchicine, Colchicine, Epoetin, Glucose, Neomycin, Neomycin, Omeprazole.
Mechanism of Action: Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Pregnancy Impact: No Studies Available
Impact During Lactation: No Studies Available
Pyridoxine - Drug Information
Typical usage: :Anaemia, Deficiency states, Idiopathic sideroblastic anaemia, Isoniazid neuropathy, Oedema and ascites in cirrhosis of the liver, Premenstrual syndrome, Schizophrenia and other psychoses, Vitamin deficiency.
Probable Side Effects: :Dizziness, Drowsiness, Blurred vision, Pain, Burning.
Drug Interaction: None mentioned.
Mechanism of Action: Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.
Thiamine Mononitrate - Drug Information
Typical usage: :Lung cancer and pancreatic cancer, mild chronic deficiency, severe deficiency, thiamine deficiency prophylaxis, thiamine deficiency treatment.
Probable Side Effects: :Nausea, urticaria, Gi bleeding, angioneurotic edema, restlessness, pruritis, pulmonary edema, hemorrhage, cyanosis,
Drug Interaction: Thiamine is known to interact with other drugs like aluminium hydroxide and oxide, amiloride (HCl), bumetanide, chlorthalidone, estradiol (Valerate), estrogens conjugated, fluorouracil, magnesium carbonate, magnesium oxides and hydroxides, metformin (HCl), phenobarbital Sodium, phenobarbitone, triamterene, vecuronium (Br). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and the recently discovered adenosine thiamine triphosphate (AThTP), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Polybion Caps 15S : Rs.16.00
|Dispatches by||Next Day|
|Composition||Cyanocobalamin 15 mcg, Pyridoxine 3 mg, Thiamine Mononitrate|
|Salt Information||Cyanocobalamin, Pyridoxine, Thiamine Mononitrate|
|Pack Size||15 Capsule|
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Substitutes of Polybion Caps 15S
Rs.1.00Cyper Drugs & Pharma
Rs.1.00Orchid Chemicals & Pharma
Rs.1.00Low Cost Standard Therapeutics (Locost)
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