Special Precautions Patient w/ propensity to bleed, low body wt (<60 kg). Patient who will undergo CABG and other surgical procedure; coronary angiography in UA/NSTEMI patients. Elderly (?75 yr). Pregnancy and lactation. Monitoring Parameters Monitor Hb and haematocrit periodically; may consider platelet function testing.
Drug-Interaction Increased risk of bleeding w/ oral anticoagulants (e.g. warfain), clopidogrel, NSAIDs and fibrinolytics.
Indications Aspirin is primarily indicated in conditions like Fever, Following coronary bypass surgery, Headache, Inflammation, Ischaemic event (unstable angina, myocardial infarction), Mild to moderate pain, Myocardial infarction, Myocardial infarction prophylaxis, Pain and inflammation (in rheumatic disease, in other musculoskeletal disorders), Prophylaxis of cerebrovascular disease, Pyrexia, Stable angina, Stable angina pectoris, Stroke prophylaxis, and can also be given in adjunctive therapy as an alternative drug of choice in Arterial thromboembolism prophylaxis, Colorectal carcinoma prophylaxis, Juvenile rheumatoid arthritis, Neurogenic bladder, Osteoarthritis.
Dosage Adult: PO Prophylaxis of MI 75-325 mg/day. Stent implantation 325 mg 2 hr pre-op, then 160-325 mg/day. Pain and fever 325-650 mg 4-6 hrly. Max: 4 g/day. Pain and inflammation associated w/ musculoskeletal and joint disorders Initial: 2.4-3.6 g/day. Maintenance: 3.6-5.4 g/day.
Contra-Indications Aspirin is contraindicated in conditions like GI ulceration,Hypoprothrombinemia,Hypersensitivity.
Side Effects The signs and symptoms that are produced after the acute overdosage of Aspirin include Coma, Acidosis, Hyperthermia, Volume depletion, Hyperglycemia, Renal failure, Hyperventilation, Cardiovascular collapse, Vertigo, Tinnitus, Hyperkalemia.
The symptomatic adverse reactions produced by Aspirin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Nausea, Vomiting, Tinnitus, Epigastric discomfort, Dyspepsia, Asthma, Respiratory alkalosis, Bleeding.Aspirin produces potentially life-threatening effects which include Cerebral hemorrhage, Airway obstruction, Gastric ulceration, Gastric erosion. which are responsible for the discontinuation of Aspirin therapy.The severe or irreversible adverse effects of Aspirin, which give rise to further complications include Urticaria, Gi bleeding, Rhinitis, Angioneurotic edema, Hepatitis, Hepatomegaly.
Special Precautions History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion, asthma or allergic disorders, dehydrated patients, uncontrolled hypertension, impaired renal or hepatic function, elderly.
Drug-Interaction Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone.May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.
Price of Prax A 75Mg 10Capsule : Rs.185.00
Aspirin 75 mg, Prasugrel 10 mg
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