Indications Ranolazine is primarily indicated in conditions like Angina, Stable angina.
Dosage Adult: PO Initial: 375 mg bid, then 500 mg bid after 2-4 wk. Max: 750 mg bid.
Contra-Indications Concomitant admin w/ potent CYP3A4 inhibitors, CYP3A4 inducers and class 1A or class III antiarrhythmics other than amiodarone. Moderate to severe hepatic and severe renal impairment (CrCl <30 mL/min).
Special Precautions Patient w/ history of long QT syndrome, known acquired QT interval prolongation, moderate to severe CHF (NYHA Class III-IV), low wt (<60 kg). Mild hepatic and mild to moderate renal impairment (CrCl 30-80 mL/min). Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Baseline and follow up ECG to evaluate QT interval; monitor renal function in patients w/ moderate to severe renal impairment, BP in patients w/ renal dysfunction; serum K levels.
Drug-Interaction Increased plasma levels w/ moderate CYP3A4 inhibitors (e.g. diltiazem, fluconazole, erythromycin), P-glycoprotein inhibitors (e.g. verapamil, ciclosporin) and CYP2D6 inhibitors (e.g. paroxetine). May increase plasma digoxin concentrations. May increase risk of rhabdomyolysis w/ simvastatin. May increase plasma concentrations of atorvastatin, other statins (e.g. lovastatin) and CYP3A4 substrates w/ narrow therapeutic range (e.g. tacrolimus, sirolimus, everolimus). May increase plasma exposure of metformin. Increased risk of ventricular arrhythmias w/ other drugs that prolong QT interval (e.g. terfenadine, astemizole, mizolastine).
Price of Randear Er 500Mg 10Tablet : Rs.63.00
Ranolazine 500 mg
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