Sebifin Plus 15Gm contains following Salts:-
Mometasone - Drug Information
Typical usage: :Dermatoses.
Probable Side Effects: :Telangiectasia, strias, skin atrophy, decrease synthesis of collagen in dermis, pruritus, erythema, burning, allergic contact dermatitis, tingling, folliculitis, acne, paresthesias, hypopigmentation.
Drug Interaction: Mometasone is known to interact with other drugs like itraconazole, prednisolone and prednisone. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Mometasone bind with high affinity to specific cytoplasmic receptors. Inflammation is decreased by diminishing the release of leukocytic acid hydrolases, prevention of macrophage accumulation at inflamed sites, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Terbinafine - Drug Information
Typical usage: :Athelets foot, dermatophyte infections of the nails, fungal infection, hair and nail infection, iron-deficiency anaemia prophylaxis or for mild iron deficiency, ringworm, skin infections, tinea corporis.
Probable Side Effects: :Nausea, vomiting, anorexia, abdominal pain, rashes, urticaria, redness, itching, increased intracranial pressure, stinging.
Drug Interaction: Terbinafine is known to interact with other drugs like cimetidine (HCl), rifampicin, tamsulosin hydrochloride. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Terbinafine acts by inhibiting squalene monooxygenase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. This inhibition also results in an accumulation of squalene, which is a substrate catalyzed to 2,3-oxydo squalene by squalene monooxygenase. The resultant high concentration of squalene and decreased amount of ergosterol.
Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Price of Sebifin Plus 15Gm : Rs.158.00
|Dispatches by||Next Day|
|Composition||Mometasone 0.1%, Terbinafine 1%|
|Salt Information||Mometasone, Terbinafine|
|Pack Size||15 gm|
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