Typical usage: :Adjunctive therapy in the treatment of partial seizures with secondary generalisation. It is particularly useful in controlling secondarily generalised tonic-clonic seizures. Neuropathic pain.
Probable Side Effects: :Flatulence, dizziness, headache, drowsiness, fatigue, ataxia, anxiety, constipation, dry mouth, rashes, dyspepsia, depression, weight gain, somnolence, tremor, asthenia, nausea and vomiting.
Drug Interaction: Gabapentin is known to interact with other drugs like cimetidine (HCl), fosphenytoin, phenytoin (Na). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters. One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of Spironova 300Mg 10Tablet : Rs.135.00
Gabapentin 300 mg
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