Probable Side Effects: :Nausea, stomach upset, skin rash, acute toxicity.
Drug Interaction: The elimination of tamsulosin from the body may be reduced by erythromycin, ketoconazole (Nizoral, Extina, Xolegel, Kuric),paroxetine (Paxil), cimetidine (Tagamet), ritonavir (Norvir), lopinavir, and other drugs that reduce the elimination of drugs by liver enzymes. Reduced elimination may lead to increased side effects of tamsulosin. PDE-5 inhibitors (for example, vardenafil [Levitra, Staxyn], Adcirca, sildenafil[Viagra, Revatio], tadalafil [Cialis]) add to the blood pressure lowering effects of tamsulosin and may result in severe blood pressure reduction.
Mechanism of Action: Tamsulosin is an oral drug for the treatment of men who are having difficulty urinating because of benign prostatic hyperplasia (BPH). In men, the tube which carries urine from the bladder to the penis (called the urethra) travels through the prostate gland. As men get older, the prostate gland enlarges, and the muscle cells within the prostate gland and the neck of the bladder (which controls the flow of urine) tighten. The combination of enlargement and tightening of muscles compresses the urethra and obstructs the flow of urine. This results in difficulty urinating and retention of urine within the bladder. The tightening or contraction of the muscle cells is controlled by nerves. One type of nerve, the alpha adrenergic nerves, cause the muscle cells to tighten by releasing a chemical related to epinephrine (adrenalin). Tamsulosin blocks the effects of this chemical on the muscle cells and causes the muscles to relax. This results in a decrease in obstruction to the flow of urine. There are other drugs which block alpha adrenergic nerves throughout the body and which are used in treating diseases of the heart, blood vessels, and prostate for example, prazosin (Minipress), terazosin (Hytrin), doxazosin (Cardura), andalfuzosin (Uroxatral). Tamsulosin is more active against the alpha adrenergic nerves of the prostate and bladder neck than these other drugs and has a lesser effect on alpha adrenergic nerves elsewhere in the body. For this reason, tamsulosin causes fewer side effects, especially low blood pressure, than other alpha adrenergic blocking drugs. Moreover, tamsulosin therapy can be started at the optimum dose whereas other alpha adrenergic blocking drugs need to be started at low doses with the doses slowly increased over time in order to minimize the side effects. Tamsulosin was approved by the FDA in 1997.
Pregnancy Impact: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Drug Interaction: Tolterodine (Tartrate) is known to interact with other drugs like amantadine, erythromycin, itraconazole, ketoconazole, miconazole (Nitrate). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Tolterodine and its active metabolite, 5-hydroxymethyltolterodine, act as competitive antagonists at muscarinic receptors. This antagonism results in inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Price of Tamlet 2Mg 10Capsule : Rs.140.00
Tamsulosin 0.4 mg, Tolterodine 2 mg
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