Uses- Atorvastatin is used to treat patients with elevated cholesterol, triglyceride or lipoprotein levels in blood, and to reduce the risk of heart diseases, even when blood cholesterol is normal. Fenofibrate is used to reduce the amount of cholesterol and triglycerides in the blood. It is used along with exercise and diet in the treatment of very high levels of cholesterol in the blood (hyper-triglyceridemia).
Comon Side Effect- Fever, Extreme tiredness, Confusion and forgetfulness, Nausea, Heartburn, Indigestion, Muscle pain, Lack of energy, Joint pain, Diarrhea
Drug Interaction: Atorvastatin is known to interact with other drugs like aliskiren, amprenavir, cimetidine (HCl), colestipol (HCl), cyclosporin A, digoxin, erythromycin, mibefradil (Di HCl), nicotinic acid, repaglinide, warfarin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway, this results in a subsequent decrease in hepatic cholesterol levels.
Pregnancy Impact: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.
Typical usage: :Hypercholesterolaemia, hyperlipoproteinaemia, prophylaxis of NSAID-associated gastric or duodenal ulcer.
Probable Side Effects: :Hepatitis, rhabdomyolysis, headache, diarrhea, myalgia, constipation, skin rashes, impotence, decrease in libido.
Drug Interaction: Fenofibrate is known to interact with other drugs like Acenocoumarol, Anisindione, Cerivastatin, Dicumarol, Lovastatin, Pravastatin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism of Action: Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III.
Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.
Price of XTOR F : Rs.145.40
Atorvastatin 10 mg, Fenofibrate 160 mg
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